Peri-implant Bone Healing: Its Basic Osteogenesis and Biomarkers
https://doi.org/10.47836/mjmhs.18.6.41
- Author:
Muhammad Amal Abd Wahab
1
;
Eleena Mohd Yusof
1
;
Rohana Ahmad
1
,
2
;
Mohd Zaki Salleh
2
;
Teh Lay Kek
2
Author Information
1. Centre for Restorative Dentistry Studies, Faculty of Dentistry, Universiti Teknologi MARA (UiTM), Sungai Buloh Campus, Jalan Hospital, 47000 Sungai Buloh, Selangor, Malaysia&
2. Integrative Pharmacogenomics Institute (iPROMISE), Level 7, FF3 Building, Puncak Alam Campus, 42300 Bandar Puncak Alam, Selangor, Malaysia
- Publication Type:Review
- Keywords:
Dental implants, Osseointegration, Osteogenesis, Proteins, Saliva, Precision health
- From:Malaysian Journal of Medicine and Health Sciences
2022;18(No.6):324-331
- CountryMalaysia
- Language:English
-
Abstract:
The continuous sequence of bone healing phases starts off with osteoconduction to the implant surface, depending on the migration of osteogenic cells. Osteoneogenesis ensues resulting in a mineralised interfacial matrix and
is followed by bone remodelling to the implant interface at discrete sites. Dental implant drilling procedure and
placement produce osseous defect which is filled by blood. Within seconds, blood proteins are adsorbed onto the
implant surface and platelets are activated resulting in the release of cytokines and growth factors. Further platelet
aggregation initiates osteoconduction to the surface, followed by osteoneogenesis, forming an extracellular matrix.
Subsequently, remodelling creates a bone to implant interface which can be explained through distance and contact
osteogenesis. The dental implant surface has been shown to influence osteoconduction by modifying protein properties and adsorption around the implant. Salivary biomarkers may be considered as a specific and sensitive diagnostic
tool to detect these changes in protein expressions after implant placement. Thus, the purpose of this narrative review
is to provide a detailed account of the bone healing mechanism associated with dental implant placement, as well as
how the implant surface architecture and protein release play a role in bone healing, and the potential use of saliva
to detect these biomarkers.
- Full text:11.2022my1391.pdf
