L-hydroxyproline changes in rats' skin induced by ultraviolet C irradiation

VernacularTitle:短波紫外线照射后大鼠皮肤羟脯氨酸含量的变化
Author: Wei SUO ; Aimin MA ; Xinglin WANG ; Dewen WANG
Publication Type:Journal Article
Keywords: ultraviolet C, L-hydroxyproline, collagen
From: Chinese Journal of Rehabilitation Theory and Practice 2003;9(11):662-663
CountryChina
Language:Chinese
Abstract: ObjectiveTo investigate the L-hydroxyproline (L-Hyp) changes in rats' skin after exposed to different doses of ultraviolet C irradiation (UVC) and the effect of UVC radiation on collagen synthesis.MethodsAfter the animal model was set up, each male Wistar rat was made three fresh skin wounds, and three skin wounds of rats were divided into the 15 MED UVC irradiation (15mJ/cm2),60 MED UVC irradiation (60mJ/cm2) and control (without UVC irradiation). Then the chemistry method was utilized to research changes of L-Hyp contents of the granulation.ResultsFrom the 21st to the 28th day after UVC irradiation, contents of L-Hyp in the 15 MED group were higher than that in controls (P<0.05). While at the 28th day, L-Hyp level in the 60 MED group increased greatly and was higher than that in other two groups (P<0.01).ConclusionUVC irradiation increases L-Hyp level in rat's wound skin, so it accelerates the collagen synthesis and is helpful to promote wound healing, and the effect of 60 MED dose is superior to that of 15 MED.