Effects of stilbene-glycoside on learning and memory function and free radicals metabolism in dementia model mice
- VernacularTitle:二苯乙烯苷对痴呆小鼠学习记忆及自由基代谢的影响
- Author:
Jin CHU
;
Cuifei YE
;
Lin LI
- Publication Type:Journal Article
- Keywords:
4'-tetrahydroxy stilbene-2-O-β-D-glycoside, β-amyloid, dementia, learning and memory, Alzheimer's disease(AD)
- From:
Chinese Journal of Rehabilitation Theory and Practice
2003;9(11):643-645
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo observe the effect of 2,3,5,4'-tetrahydroxy stilbene-2-β-D-glycoside(TSG) on learning and memory ability and free radicals metabolism in dementia model mice induced by β-amyloid (Aβ).MethodsAβ1-40 was given to the right lateral ventricle in the model group, and the TSG had been administered to the therapy group for 8 weeks by gastrogavage.All the mice of different groups were tested with Morris water maze and step-through test. Then the mice were killed and biochemical assays of neurol MDA,MAO-B,T-AOC were performed.ResultsThe model mice showed worse ability in learning and memory compared with control mice. The MDA cotent, MAO-B activity in the cortical increased in model mice compared with normal control; TSG reduced the MDA content, MAO-B activity,and increased T-AOC activity.ConclusionTSG can improve the learning and memory ability of model mice, decrease peroxidation level of brain, and increase antioxidation ability of brain, which suggest that TSG may have a promising application in treatment of dementia disease such as AD.
