Effects of 2,3,5,4'-tetrahydroxy stilbene-2-O-β-D-glucoside on water content and the metabolism of free radicals in brain of ischemia mice
- VernacularTitle:二苯乙烯苷对脑缺血小鼠脑组织含水量及自由基代谢的影响
- Author:
Zhijun LIU
;
LIn LI
;
Cuifei YE
;
Houxi AI
- Publication Type:Journal Article
- Keywords:
tetrahydroxystilbene-2-O-β-D-glucoside(TSG), cerebral ischemia, brain edema, free radicals, mouse
- From:
Chinese Journal of Rehabilitation Theory and Practice
2003;9(11):641-642
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo explore the mechanism of protection of 2,3,5,4'-tetrahydroxy stilbene-2-O-β-D-glucoside(TSG) on brain.MethodsThe bilateral carotid arteries of mice were occluded and then reperfused. The mice were sacrificed to get the brain tissue. Brain water content(BWC) was assayed by dry-wet method; malondialdehyde (MDA) content was determined by thiobarbiturate method and the activity of superoxide dismutase(SOD) was estimated by nitrite salt assay.ResultsBWC of model group was significantly higher than that of sham-operation group, while the TSG treatment reduced the BWC remarkably in mice with ischemia-reperfusion. SOD activity of model group was significantly lower than that of sham-operation group, while MDA content increased remarkably. Comparing with the model group, the SOD activity of mice treated with TSG was higher and the MDA content was lower.ConclusionTSG may reduce brain edema, improve the anti-oxidative ability of the brain tissue, and therefore, have protective effects on the brain.
