Minocycline Protects Against LPS-induced Neuronal Death and Memory Impairment in the Rat
https://doi.org/10.47836/mjmhs.18.6.29
- Author:
Entesar Yaseen Abdo Qaid
1
,
2
;
Zuraidah Abdullah
1
;
Rahimah Zakaria
3
;
Idris Long
1
Author Information
1. School of Health Sciences, Universiti Sains Malaysia, Health Campus, Kubang Kerian, 16150, Kelantan&
2. Histology Department, Faculty of Medicine and Health Sciences, Taiz University, Taiz, Yemen
3. School of Medical Sciences, Universiti Sains Malaysia, Health Campus, Kubang Kerian, 16150, Kelantan
- Publication Type:Journal Article
- Keywords:
Alzheimer’s disease, Minocycline, Cognitive impairment, Neuroinflammation, Memantine
- From:Malaysian Journal of Medicine and Health Sciences
2022;18(No.6):220-227
- CountryMalaysia
- Language:English
-
Abstract:
Introduction: Minocycline has been demonstrated to have potent effects on neurologic structures and functions in
several animal models. However, its neuroprotective properties following a single injection of lipopolysaccharide
(LPS) in an adult rat model have not been clearly elucidated. This study investigated minocycline’s neuroprotective
effects in the LPS-induced neuroinflammation rat model. Methods: Fifty adult male Sprague Dawley rats were split
into five groups at random: (i) control, (ii) distilled water-treated LPS, (iii) 25 mg/kg minocycline-treated LPS, (iv) 50
mg/kg minocycline-treated LPS, and (v) 10 mg/kg memantine-treated LPS. On day 5, LPS (5 mg/kg) was given intraperitoneally once, whereas minocycline and memantine were given once daily for 14 days. Results: LPS was found
to significantly induce β-amyloid peptide deposition and neuronal damage, and impair recognition memory, while
administration of minocycline dose-dependently reversed these effects. These data suggest that LPS-induced recognition memory impairment by inducing β-amyloid peptide deposition and neuronal damage in the cortical and hippocampal areas. Furthermore, we compared minocycline with memantine administration, and these data suggested
better effects in minocycline (50 mg/kg) and comparable effects between minocycline (25 mg/kg) and memantine (10
mg/kg) treatments in reducing β-amyloid peptide deposition, neuronal damage and recognition memory impairment
induced by LPS. Conclusion: Minocycline may be a strong contender as an effective preventive-therapeutic drug for
neuroinflammatory diseases such as Alzheimer’s disease (AD) based on these findings.
- Full text:11.2022my1379.pdf
