Advances in Mechanotransduction Pathway of Macrophage
10.16156/j.1004-7220.2023.02.30
- VernacularTitle:巨噬细胞力学信号转导通路的研究进展
- Author:
Jiaqi SHAO
1
;
Juan LI
1
;
Jun LIN
1
Author Information
1. Department of Stomatology, the First Affiliated Hospital, Zhejiang University School of Medicine
- Publication Type:Journal Article
- Keywords:
biomechanics;
mechanotransduction;
macrophage polarization;
biomaterials
- From:
Journal of Medical Biomechanics
2023;38(2):E408-E414
- CountryChina
- Language:Chinese
-
Abstract:
Mechanical stimulation in micro-environment ( such as matrix stiffness, surface topography, cyclical stretch) can be perceived by macrophages through receptors on cell membrane, transmitted to the nucleus along the adhesion protein molecular chain and cytoskeleton, and also converted into biochemical signal to stimulate gene transcription. Mechanical stimulation drives various biological functions in macrophages, such as adhesion, proliferation, migration, and polarization, thereby playing a corresponding role in disease progression and tissue regeneration. This study demonstrates the role of micro-environment mechanics in macrophages polarization and function, and elucidates the related mechanism of mechanotransduction pathway in macrophages, so as to provide molecular biomechanics insights into the development of macrophage-targeting immunomodulatorybiomaterials.
