Stress Relaxation Behavior of Collagen Type II- Silk Fibroin Composite Cartilage Scaffold under Different Degradation Cycles
10.16156/j.1004-7220.2023.02.19
- VernacularTitle:不同降解周期下Ⅱ型胶原-丝素蛋白复合软骨支架的应力松弛行为
- Author:
Zhiyun SONG
1
,
2
;
Lilan GAO
1
,
3
,
4
;
Ying WEI
1
,
2
;
Yansong TAN
1
,
2
;
Ruixin LI
5
;
Chunqiu ZHANG
1
,
2
Author Information
1. Tianjin Key Laboratory for Advanced Mechatronic System Design and Intelligent Control, Tianjin University of Technology
2. National Demonstration Center for Experimental Mechanical and Electrical Engineering Education (Tianjin University of Technology)
3. National Demonstration Center for Experimental Mechanical and Electrical Engineering Education (Tianjin University of Technology
4. Tianjin Enterprise Key Laboratory on Hyaluronic Acid Application Research
5. Central Laboratory, Tianjin Stomatological Hospital
- Publication Type:Journal Article
- Keywords:
cartilage scaffold;
in vitro degradation;
stress relaxation;
constitutive model
- From:
Journal of Medical Biomechanics
2023;38(2):E331-E337
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study stress relaxation behaviors of cartilage scaffolds under different degradation cycles by using finite element analysis combined with theoretical models. Methods Based on the established degradation theoretical model, the elastic modulus of the scaffold was calculated under different degradation cycles. The finite element model of cartilage scaffolds was established and stress relaxation simulation was performed to analyze the variation of scaffold relaxation stress with time. The stress relaxation constitutive model was established to predict mechanical properties of the scaffold. Results The elastic modulus of cartilage scaffolds at 14 th, 28th, 42nd, 56th day after degradation was 32. 35, 31. 12, 29. 91, 28. 74 kPa, respectively. The upper layer for cartilage scaffolds was the largest. The overall relaxation stress of the scaffold decreased rapidly with time and then tended to be stable. At 8th week after degradation, the stress which the scaffold couldwithstand was still within the physiological load range of the cartilage. The predicted results of the stress relaxation constitutive model were in good agreement with the finite element simulation results. Conclusions The elastic modulus of the scaffold gradually decreases with the increase of degradation time. The longer the degradation period is, the less stress the scaffold can withstand. At the same degradation period, the larger the applied compressive strain, the larger the stress on the scaffold. Both the finite element simulation and stress relaxation constitutive model can effectively predict stress variations of cartilage scaffolds under degradation
