Biomechanical Characteristics of Idiopathic Pulmonary Fibrosis
10.16156/j.1004-7220.2023.01.29
- VernacularTitle:特发性肺纤维化的生物力学特性
- Author:
Meihao SUN
1
;
Fanli JIN
1
;
Jiansheng LI
1
;
Hui REN
2
,
3
;
Han LIU
1
Author Information
1. Henan Key Laboratory of Chinese Medicine for Respiratory Disease, Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases Co-Constructed by Henan & Ministry of Education of China, Academy of Chinese Medicine Sciences, Henan University of Chinese Medicine
2. Department of Respiratory and Critical Care Medicine, the First Affiliated Hospital of Xi’an Jiaotong University
3. Bioinspired Engineering & Biomechanics Center
- Publication Type:Journal Article
- Keywords:
idiopathic pulmonary fibrosis;
biomechanics;
matrix stiffness;
in-vitro models;
targeted therapies
- From:
Journal of Medical Biomechanics
2023;38(1):E195-E201
- CountryChina
- Language:Chinese
-
Abstract:
Idiopathic pulmonary fibrosis (IPF) is a common chronic interstitial fibrotic disease. During the fibrosis process, myofibroblasts are abnormally activated, collagen is deposited in large quantities and the biomechanical characteristics of lung tissue are significantly altered. In this paper, a systematic review about the changes in lung tissues, cellular biomechanical properties and biomechanical signals during the process of IPF was presented, and the in vitro reproduction of biomechanical features and therapeutic strategies for targeting biomechanics wassummarized, so as to provide references for clinical prevention and treatment of IPF.
