Fluid-Structure Interaction Simulation of Carotid Plaque
10.16156/j.1004-7220.2023.01.17
- VernacularTitle:颈动脉斑块的流固耦合数值模拟
- Author:
Dongdong WAN
1
;
Peng HE
2
;
Wu ZHANG
3
,
4
;
Xiaolong GAO
5
;
Jiang XIE
2
Author Information
1. School of Mechanics and Engineering Science,Shanghai University
2. School of Computer Engineering and Science,Shanghai University
3. School of Mechanics and Engineering Science
4. Shanghai Institute of Applied Mathematics and Mechanics, Shanghai University
5. Department of Radiology, Luodian Hospital of Shanghai Baoshan District
- Publication Type:Journal Article
- Keywords:
fluid-structure interaction (FSI);
carotid artery stenosis;
wall shear stress (WSS);
hemodynamics
- From:
Journal of Medical Biomechanics
2023;38(1):E116-E122
- CountryChina
- Language:Chinese
-
Abstract:
Objective To propose a two-way fluid-structure interaction (FSI) method based on real patients with carotid artery stenosis, and analyze the hemodynamic parameters of carotid plaques with different types at the lesion as well as deformation and stress changes of the plaque itself. Methods Three-dimensional ( 3D) modeling was performed based on computed tomography angiography ( CTA) data of patients with moderate carotid artery stenosis. The carotid artery wall model and plaque model were separated, and transient fluid structure coupling calculation was performed. The situation from early stage of carotid atherosclerosis to formation of the plaque was simulated. The plaque types were divided into thickened plaques, lipid plaques, mixed plaques and calcified plaques, among which thickened plaques were regarded as non-plaque conditions for representing the thickening of vascular intima-media. The stenotic carotid arteries with different plaque types were compared and analyzed. Results The plaques with different types had little effect on the overall blood flow, but the wall shear stress of lipid plaques at the lesion was lower than that of other plaques. With thickened plaques as a control, concurrence of the plaque would inhibit artery expansion, and lipid plaques were the most obvious. Calcified plaques had the highest average plaque structure stress, while lipid plaques had the lowest average plaque structure stress. Conclusions The method proposed in this study can analyze fluid area and solid area at the same time. The results can contribute to better understanding the influence of different plaque types on carotid artery diseases.
