Research Progress on Biomechanics and Mechanobiology of Articular Cartilage in 2022
10.16156/j.1004-7220.2023.01.02
- VernacularTitle:关节软骨生物力学与力学生物学 2022 年研究进展
- Author:
Chunqiu ZHANG
1
;
Lilan GAO
1
Author Information
1. National Demonstration Center for Experimental Mechanical and Electrical Engineering Education,Tianjin Key Laboratory for Advanced Mechatronic System Design and Intelligent Control, Tianjin University of Technology
- Publication Type:Journal Article
- Keywords:
articular cartilage;
loading;
arthritis;
biomechanics;
mechanobiology
- From:
Journal of Medical Biomechanics
2023;38(1):E004-E013
- CountryChina
- Language:Chinese
-
Abstract:
As a kind of elastic load-bearing connective tissues on bone surface in dynamic joints, articular cartilage can provide low wear lubrication, shock absorption, load transfer and other supporting functions, and has hierarchical fiber composite structures and excellent mechanical properties. As an avascular and aneural tissue,the degenerated articular cartilage lacks the capability of self-healing after damage. The high incidence of arthritisis still a hot spot in basic and clinical researches. Articular cartilage is a mechanical sensitive tissue, andmechanical environment will affect the development of tissues in different directions. Extensive researches onbiomechanics and mechanobiology of articular cartilage were conducted in 2022. Many studies on morphology, function and mechanical state of cartilage,as well as mechanical state of cartilage under different conditions were reported. Some cartilage-related loading devices were designed at animal, tissue and cell levels. Researches onthe repair of cartilage degeneration and injury under mechanical loads were carried out in vitro and in vivo, andsome important repair method and means were obtained. The biomechanical and mechanobiology research on articular cartilage is the basis of arthritis, cartilage defect and repair. The influence of quantitative mechanical under 4 conditions on the repair of articular cartilage injury needs further study in vivo and in vitro
