Research progress of novel bispecific monoclonal antibody Faricimab in the treatment of diabetic macular edema and age-related macular degeneration
10.3980/j.issn.1672-5123.2023.10.15
- VernacularTitle:新型双特异性单抗Faricimab治疗糖尿病性黄斑水肿及年龄相关性黄斑变性的研究进展
- Author:
Xin-Li WEI
1
;
Ke-Ke HU
1
;
Yu-Ru DU
1
;
Yan-Nian HUI
1
;
Hong-Jun DU
1
Author Information
1. rst authors: Xin-Li Wei and Ke-Ke Hu
- Publication Type:Journal Article
- Keywords:
Faricimab;
diabetic macular edema;
age-related macular degeneration;
vascular endothelial growth factor;
angiopoietin-2(Ang-2);
efficacy;
safety
- From:
International Eye Science
2023;23(10):1677-1682
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic macular edema(DME)and age-related macular degeneration(ARMD)are the leading causes of visual impairment and blindness worldwide, and their common pathological features are increased vascular permeability and abnormal neovascularization, in which cytokines such as vascular endothelial growth factor(VEGF)and angiopoietin-2(Ang-2)play an important role. Intravitreal injection of anti-VEGF agents significantly changed the clinical management of DME and ARMD, but limitations such as the non-responsive cases, the treatment burden and risks caused by frequent injections need to be overcome. Faricimab, a novel bispecific monoclonal antibody that simultaneously targets VEGF-A and Ang-2, can effectively reduce vascular permeability, decrease the number of neovascularization and alleviate retinal edema. Registered clinical studies have shown that Faricimab is effective in improving vision and reducing retinal edema, which is non-inferior to Aflibercept and Ranibizumab, maintains a long dosing interval, and has a high safety profile. This article reviews the latest advances in the treatment of DME and ARMD with Faricimab.
