Recalibrated scales: The use of low-dose Isotretinoin in a case of Epidermolytic Ichthyosis-NPS1 in a Filipino child
- Author:
Erickah Mary Therese R. Dy
1
;
Shahara Abalos-Babaran
1
;
Monette R. Faner
1
;
Carmela Augusta F. Dayrit-Castro
1
Author Information
- Publication Type:Case Reports
- MeSH: Hyperkeratosis, Epidermolytic; Isotretinoin
- From: Acta Medica Philippina 2021;55(5):592-596
- CountryPhilippines
- Language:English
- Abstract: Epidermolytic Ichthyosis (EI) is a rare non-syndromic keratinopathic ichthyosis without definitive treatment. This is a case of EI in a 5-year-old Filipino female who presented with hyperkeratotic scales sparing the palms and soles. Histopathology revealed epidermolytic hyperkeratosis. A trial of treatment with isotretinoin 0.3 mg/kg/day, together with keratolytic agents, urea lotion and lactic acid lotion, resulted in a marked decrease in the thickness of the scales and odor. Interestingly, rebound effects were noted at 0.6 mg/kg/day. Taking into account that EI presents with more skin fragility compared to non-EHK ichthyosis, the authors surmise that there may be a smaller treatment window for patients with EI, which is notably lower than recommended for ichthyosis in general.
- Full text:2893-Article Text-37489-1-10-20210827.pdf
