Decoded: A case report on dedifferentiated Liposarcoma on the Gluteal area

Author: Juan Paolo David S. Villena ¹ ; Eileen Liesl A. Cubillan ¹ ; Ann Camille Q. Yuga ²
Author Information

1. Department of Dermatology, Philippine General Hospital, University of the Philippines Manila
2. Department of Surgery, Philippine General Hospital, University of the Philippines Manila
Publication Type:Case Reports
MeSH: Liposarcoma; Immunohistochemistry
From: Acta Medica Philippina 2021;55(5):544-550
CountryPhilippines
Language:English
Abstract: Dedifferentiated liposarcoma is a soft tissue sarcoma of adipocytic lineage. Histopathology and immunohistochemistry are essential for diagnosis. A 51-year-old Filipino woman presented with a rapidly enlarging left gluteal tumor. Histopathology revealed a multilobulated tumor having prominent myxoid stroma with numerous stellate-shaped, atypical cells bearing atypical mitotic figures. Other lobules were composed of sheets of pleomorphic cells, with atypical mitotic figures. The tumor stained positively with alcian blue, vimentin, MDM2 and p16 stains. Other immunohistochemical (IHC) studies done (pancytokeratin, CK7, CK 20, CD 34, CEA, desmin, EMA, SMA, S100) showed negative results. After a 2 cm wide excision of the sarcoma, patient was free from local tumor recurrence for 2 months, after which she was lost to follow-up. We report this case and a brief review of the current literature on dedifferentiated liposarcoma.
Full text:2005-Article Text-37456-1-10-20210827.pdf