Experimental study of the protective effect of combined medication on acute cerebral ischemic reperfusion injury
- VernacularTitle:联合用药在急性脑缺血再灌注损伤中保护作用的实验研究
- Author:
Chun-hua PIAO
;
Shu-rong JI
;
Jian-peng XU
- Publication Type:Journal Article
- Keywords:
ischemia-reperfusion, nimodipine, mannitol, combined medication, synergistic action
- From:
Chinese Journal of Rehabilitation Theory and Practice
2002;8(9):529-530
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo study neural protective effect of combined medication with nimodipine and mannitol on injury of cerebral ischemia-reperfusion for screening the better medication method in acute cerebral ischemia-reperfusion. MethodsA model of cerebral ischemia-reperfusion was performed by clipping bilateral common carotid artery of rats with vago- and releasing them 3 hours later. 40 Wistar female rats within 1 month were divided into 5 groups randomly with 8 rats each: model group (no use of medicine), nimodipine group(0.2mg/kg), mannitol group(0.5g/kg), nimodipine and mannitol group, sham-operated group (no use of medicine and no clipping process). The changes of SOD and MDA in brain tissue were measured 24 hours after cerebral ischmic reperfusion in all groups. At the same time pathologic study was performed to compare the different groups.ResultsThere were significant differences between nimodipine and mannitol group and other groups in changes of SOD, MDA and pathological changes(P<0.01). Conclusions Combined medication with nimodipine and mannitol is the better way to protect brain tissue from acute cerebral ischemia-reperfusion than other way in present experiment, by synergistic action.
