The Relationship of the Estimates of Effective Concentration Calculated by Logit, Probit, and Sigmoid Emax.
10.4097/kjae.2002.43.3.345
- Author:
Soo il LEE
1
;
Gi Baeg HWANG
;
Chang Yeoul BAIK
Author Information
1. Department of Anesthesiology, Dong-A University College of Medicine, Busan, Korea. silee@daunet.donga.ac.kr
- Publication Type:Original Article
- Keywords:
Logit;
pharmacodynamics;
probit;
sigmoid Emax
- MeSH:
Colon, Sigmoid*;
Vecuronium Bromide
- From:Korean Journal of Anesthesiology
2002;43(3):345-347
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: This study is to demonstrate that the estimates of effective concentration (EC) inferred by logit, probit, and sigmoid Emax can be declared to be similar. METHODS: The estimates of EC (5, 25, 50, 75, 95 [%]) of 24 vecuronium concentration-single twitch response data were obtained with three pharmacodynamic methods. A paired t-test with Bonferroni's correction was used. RESULTS: The distribution of estimates by probit were narrower than that of those by logit and sigmoid Emax. The estimates of logit and sigmoid Emax were closely similar. CONCLUSIONS: It suggests that the EC estimates of other paper analysed by the different pharmacodynamic method could be lower or higher.
