Study on prospective memory deficits of obsessive-compulsive disorder patients in the endophenotype framework
10.11886/scjsws20210225001
- VernacularTitle:强迫症患者前瞻记忆缺损性质及内表型
- Author:
Zhen WEI
1
;
Jiasheng YU
2
;
Zhongqiang RUAN
2
;
Qiong YANG
3
Author Information
1. Shenzhen Maternity and Child Healthcare Hospital， Shenzhen 518028， China
2. School of psychology/Center for Studies of Psychological Application， South China Normal University， Guangzhou 510631， China
3. Affiliated Brain Hospital of Guangzhou Medical University， Guangzhou 510370， China
- Publication Type:Journal Article
- Keywords:
Obsessive-compulsive disorder;
Prospective memory;
Endophenotype
- From:
Sichuan Mental Health
2021;34(3):220-225
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo study the prospective memory deficits of obsessive-compulsive disorder patients and unaffected first-degree relatives of patients， so as to validate the possibility of prospective memory as an endophenotype of obsessive-compulsive disorder. MethodsHealthy controls， obsessive-compulsive disorder patients and unaffected first-degree relatives of patients， each with 25 cases， matched for age， education， gender， IQ and marriage status were enrolled. The standardized prospective memory paradigm with a multi-trial design was conducted， and the accuracy was used as an indicator of prospective memory function. ResultsThe accuracy of event- and time-based prospective memory tasks of obsessive-compulsive disorder patients was lower than that of healthy controls， with statistical differences ［（0.74±0.24） vs. （0.88±0.13）， d=-0.140， P=0.044； （0.77±0.21） vs. （0.93±0.10）， d=-0.164， P=0.011］. The accuracy of event-based prospective memory task of unaffected first-degree relatives was also lower than that of healthy controls， with statistical difference ［（0.73±0.20） vs. （0.88±0.13）， d=-0.144， P=0.036］. ConclusionObsessive-compulsive disorder patients has extensive prospective memory deficits， indicating that prospective memory may be an endophenotype of obsessive-compulsive disorder.
