Predictive role of the degree of prospective memory impairment on treatment response to SSRIs in patients with obsessive-compulsive disorder
10.11886/scjsws20210512001
- VernacularTitle:强迫症患者前瞻记忆缺损程度对SSRIs疗效的预测作用
- Author:
Zhen WEI
1
;
Jiasheng YU
2
;
Zhongqiang RUAN
2
;
Qiong YANG
3
Author Information
1. Affiliated Shenzhen Maternity and Child Healthcare Hospital， Southern Medical University， Shenzhen 518028， China
2. School of Psychology/Center for Studies of Psychological Application， South China Normal University， Guangzhou 510631， China
3. Affiliated Brain Hospital of Guangzhou Medical University， Guangzhou 510370， China
- Publication Type:Journal Article
- Keywords:
Obsessive-compulsive disorder;
Prospective memory;
SSRIs;
Outcome prediction
- From:
Sichuan Mental Health
2021;34(4):336-340
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo explore the predictive role of the degree of prospective memory impairment on the treatment response to Selective Serotonin Reuptake Inhibitors （SSRIs） in patients with obsessive-compulsive disorder. MethodsA total of 30 patients with obsessive-compulsive disorder who met the diagnostic criteria of the Diagnostic and Statistical Manual of Mental Disorders， fourth edition， text revision （DSM-IV-TR） were selected， and all patients were treated with SSRIs for 4 weeks. The severity of obsessive-compulsive symptom was assessed using Yale-Brown Obsessive Compulsive Scale （Y-BOCS）， and the efficacy was evaluated by the reduction rate of Y-BOCS score. Moreover， the performance of event-based， time-based and activity-based prospective memory tasks were compared before and after treatment. ResultsAfter treatment， the total Y-BOCS score of patients was lower than before treatment ［（27.07±4.63） vs. （24.87±5.93）， F（1，29）=4.984， P=0.033］， meantime， the performance of event- and time- based prospective memory tasks was improved ［（0.78±0.21） vs. （0.88±0.11）， F（1，29）=9.022， P=0.005； （0.81±0.17） vs. （0.91±0.11）， F（1，29）=9.063， P=0.005］. Correlation analysis showed that the performance of event-based prospective memory at baseline was positively correlated with the reduction of Y-BOCS score （r=0.478， P=0.014）. The event-based prospective memory performance at baseline could positively predict the treatment response to SSRIs treatment in patients （β=0.441， P=0.014）. ConclusionThe event-based prospective memory function of patients with obsessive-compulsive disorder can positively predict SSRIs treatment outcome， and patients with better prospective memory performance yield better treatment responses.
