Plasma Fibronectin Levels in Patients with Psoriasis.
- Author:
Ki Young SUNG
;
Sang Lip CHUNG
- Publication Type:Original Article
- Keywords:
Plasrna fibronectin;
Fsoriasis
- MeSH:
Carcinoma, Basal Cell;
Carcinoma, Squamous Cell;
Chromatography, Affinity;
Connective Tissue;
Connective Tissue Diseases;
Extracellular Matrix;
Female;
Fibronectins*;
Gelatin;
Glycoproteins;
Humans;
Immunoelectrophoresis;
Plasma*;
Psoriasis*;
Sepharose
- From:Korean Journal of Dermatology
1989;27(5):495-501
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Fibronectin(FN) is a physiologic glycoprotein presenton cell surface and in connective tissue, extracellular matrix and plasma. Increased plasma FN levels have been reported in the patients with psoriasis, connective tissue disease, internal malignancy, squamous cell carcinoma and basal cell carcinoma. The author investigated the plasma FN levels in 30 patients (males 13, female 17) with psoriasis and 23 healthy subjects (male 13, female 10) by gelatin sepharose 4B affinity chromatography and Laurells rocket immunoelectrophoresis method. The results were as follows : Plasrna JN levels were 450.4+/-80.3pg/ml in the patients with psoriasis and 334.0-51.3pg/ml in healthy subjects. There was no relationship between age graups and sex. Plasrna FN levels in the patients with psoriasis were higher than those of healthy subjects(p<0.001). There was no relationship between the levels of plasma FN and clinical severity of psoriasis.
