Effect of antipsychotics on serum uric acid in patients with schizophrenia： a Meta-analysis
10.11886/scjsws20210520001
- VernacularTitle:抗精神病药物对精神分裂症患者血尿酸水平影响的Meta分析
- Author:
Wenyan ZHANG
1
;
Longfei LI
2
;
Xiaohui SONG
3
;
Wu LI
2
Author Information
1. School of Mental Health， Jining Medical College， Jining 272067， China
2. Jining Mental Health Center， Jining 272051， China
3. Second Clinical Medical College of Jining Medical College， Jining 272000， China
- Publication Type:Journal Article
- Keywords:
Oxidative stress;
Schizophrenia;
Serum uric acid;
Antipsychotics;
Meta-analysis
- From:
Sichuan Mental Health
2021;34(6):522-528
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the impact of antipsychotics on serum uric acid level in patients with schizophrenia， and to clarify the antioxidant properties of antipsychotics， so as to provide evidence-based guidelines for the treatment of schizophrenia. MethodsKeywords combined with free-text search strategies were used to retrieve English and Chinese databases including PubMed， Embase， Web of Science， Cochrane Library， CNKI， Wanfang Database， VIP database and Chinese Biomedical Literature Database. Randomized controlled trials related to the effects of antipsychotics on serum uric acid level in patients with schizophrenia were included. Meta-analysis was performed using RevMan 5.3. ResultsA total of 9 kinds of antipsychotics and 1 434 schizophrenia patients in 15 Chinese and English literatures were included. Meta-analysis showed that olanzapine （MD=14.01， 95% CI： 2.39~21.62， P<0.05） and chlorpromazine （MD=51.36， 95% CI： 42.15~60.57， P<0.05） increased the serum uric acid level in schizophrenia patients， while risperidone， aripiprazole， clozapine， haloperidol， quetiapine and ziprasidone had no significant effect on serum uric acid （P>0.05）. ConclusionThe effect of different kinds of antipsychotics on serum uric acid level in schizophrenia patients varies， among which olanzapine and chlorpromazine can elevate serum uric acid level in patients with schizophrenia， whereas no other antipsychotics have been found to have any effect on serum uric acid level.
