Anti-mGluR5 encephalitis with mental disorders as the initial symptom： a case report

Chenglong MO; Haian Lai; Ben Chen; Junyu Chen; Yayong Cui; Xin Che; Cong Zou; Dong Zheng; Haishan Shi; Le Hou

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Anti-mGluR5 encephalitis with mental disorders as the initial symptom： a case report

VernacularTitle:以精神障碍为首发症状的抗mGluR5脑炎1例
Author: Chenglong MO ¹ ; Haian LAI ¹ ; Ben CHEN ¹ ; Junyu CHEN ¹ ; Yayong CUI ¹ ; Xin CHE ¹ ; Cong ZOU ¹ ; Dong ZHENG ¹ ; Haishan SHI ¹ ; Le HOU ¹
Author Information

1. The Affiliated Brain Hospital of Guangzhou Medical University， Guangzhou 510000， China
Publication Type:Journal Article
Keywords: Anti-mGluR5; Autoimmune encephalitis; Limbic encephalitis; Hodgkin lymphoma; Hormonal immunity
From: Sichuan Mental Health 2022;35(4):366-369
CountryChina
Language:Chinese
Abstract: This article reported the clinical features of a rare patient with anti-metabotropic glutamate receptor 5 （mGluR5） encephalitis with mental disorders as the initial symptom， so as to provide references for clinical diagnosis and treatment. The patient was a 38-year-old male， developed pharyngeal pain as prodromal symptoms， and the main clinical manifestations included rapidly progressive memory loss， anxiety and depression， and psychomotor excitement symptoms including irritability and impulsive behaviors. The disease had a progressive deterioration. In the most severe state， the patient became unconscious in a shallow coma， with further cognitive decline， hallucinations and delusions， and lack of self-awareness. Both cerebrospinal fluid and serum anti-mGluR5 antibody were strongly positive （1∶100）. After two sessions of hormone shock therapy， the patient showed significantly improvement in consciousness， cognitive， emotional and psychiatric dimensions.