Research progress of anti-inflammatory agents in the treatment of major depressive disorder
10.11886/scjsws20230807001
- VernacularTitle:具有抗炎作用的药物在抑郁症治疗中的研究进展
- Author:
Yue DU
1
;
Xiao YANG
1
;
Xiaohong MA
1
Author Information
1. Mental Health Center， West China Hospital of Sichuan University， 610041 Chengdu， China
- Publication Type:Journal Article
- Keywords:
Major depressive disorder;
Anti-inflammatory effects;
Efficacy;
Inflammatory mechanism
- From:
Sichuan Mental Health
2023;36(4):289-293
- CountryChina
- Language:Chinese
-
Abstract:
Major depressive disorder is one of the common mental disorders， and its pathogenesis is not yet fully understood. Elevated levels of inflammation are recognized as one of the mechanisms contributing to the onset of major depressive disorder. Numerous studies have indicated that non-steroidal anti-inflammatory drugs， omega-3 fatty acids， statins， pioglitazone， minocycline， N-acetylcysteine， corticosteroids and other medications may exert anti-depressant effects through their anti-inflammatory actions. This article provides a comprehensive review of the application of these drugs in the treatment of major depressive disorder， exploring the therapeutic effects and potential mechanisms of action of different anti-inflammatory agents， thereby offering a reference for the future application of anti-inflammatory interventions in the treatment of depression. ［Funded by The Ministry of Science and Technology of the People's Republic of China （Number， 2022ZD0211700）］
