Randomized, double-blind, controlled trial on the efficacy of 12.5% pomelo peel ointment versus 2% mupirocin ointment in the management of localized impetigo contagiosa
- Author:
Anna Liza Chiu
1
;
Lalaine Visitacion
1
,
2
,
3
,
4
Author Information
- Publication Type:Journal Article
- Keywords: Antimicrobial
- MeSH: Anti-Infective Agents, Local; Citrus; Staphylococcus aureus
- From: Southern Philippines Medical Center Journal of Health Care Services 2019;5(2):1-6
- CountryPhilippines
- Language:English
-
Abstract:
Background:Extracts from several citrus plants have antimicrobial properties and have been used for certain infectious skin conditions.
Objective:To compare the efficacy of 12.5% pomelo peel ointment and 2% mupirocin ointment in the management of localized impetigo contagiosa.
Design:Randomized, double-blind, controlled trial.
Setting:Dermatology Outpatient Clinic in Southern Philippines Medical Center, Davao City, from September 2012 to November 2012.
Participants:46 male and female patients, aged 2-15 years old, and clinically diagnosed with localized impetigo contagiosa.
Interventions :Participants were randomized to receive either 12.5% pomelo peel ointment (PPO) or 2% mupirocin ointment (MO), thinly applied on impetigo lesions twice daily for 7 days.
Main outcome measures:Clinical success defined as either ‘complete resolution of lesions’ or ‘dryness of the lesions without crusts, with intact skin, and with no to minimal local erythema’ at any time within 7 days from the start of intervention.
Main results:The 23 patients in 12.5% PPO group had similar baseline demographic and clinical characteristics as the 23 patients in the 2% MO group. Within 7 days from the start of intervention, 15 of the 23 patients (65.22%) in the PPO group and 19 of the 23 patients (82.61%) in the MO group had clinical success (p=0.1792).
Conclusion:Pomelo peel ointment is as efficacious as mupirocin ointment in the management of localized impetigo contagiosa. - Full text:CHIU_8JUL21 WEB.pdf
