Research progress on the mechanism of promoting fracture healing by traditional Chinese medicine monomer components and compound formulas
- VernacularTitle:中药单体成分及复方促进骨折愈合的作用机制研究进展
- Author:
Zhihong ZHANG
1
;
Yanping SUN
1
;
Donghui PENG
1
;
Na CUI
1
;
Yuanning ZENG
2
;
Haixue KUANG
1
;
Qiuhong WANG
1
Author Information
1. Key Laboratory of Basic and Application Research of Beiyao （Ministry of Education），College of Pharmacy，Heilongjiang University of Chinese Medicine，Harbin 150040，China
2. School of TCM，Guangdong Pharmaceutical University，Guangzhou 510006，China
- Publication Type:Journal Article
- Keywords:
traditional Chinese medicine;
monomer components;
compound formulas;
fracture healing;
signaling pathway
- From:
China Pharmacy
2023;34(17):2172-2176
- CountryChina
- Language:Chinese
-
Abstract:
Traditional Chinese medicine has the characteristics of multiple components， pathways， and targets in the treatment of fracture healing， and has good therapeutic advantages and potential for fractures with complex pathological mechanisms. Based on this， the author summarized the mechanism of promoting fracture healing by the monomer components and compound formulas of traditional Chinese medicine and found that visfatin A， puerarin， and others can activate the mitogen-activated protein kinase （MAPK） signaling pathway； Xugudan， Guben zenggu formula and others can activate bone morphogenetic protein （BMP） signaling pathway； baicalin， Achyranthes bidentata polysaccharides and others can activate Wnt/β -catenin signaling pathway； apigenin， notoginsenoside and others can activate receptor activator of nuclear factor-κB （NF-κB）/receptor activator of NF-κB ligand/osteoprotegerin （RANK/RANKL/OPG） signaling pathway； Compound huoxue jiegu capsule， Jiangu granule and others can inhibit phosphoinositide 3-kinase/protein kinase B （PI3K/AKT） signaling pathway； icariin can activate Notch signaling pathway； Taohong siwu decoction， crocin and others can activate Hippo signaling pathway； jujuboside A and osthole can inhibit NF-κB signaling pathway， and thus promote fracture healing.
