Optimization of water extraction process of Maxing kechuan granules
- VernacularTitle:麻杏咳喘颗粒的水提工艺优化
- Author:
Dongqian LIANG
1
;
Jingjing WANG
1
;
Xin WANG
2
;
Tianchuan CHAI
3
;
Chunhua LI
1
,
4
Author Information
1. College of Pharmacy，Hebei University of Chinese Medicine，Shijiazhuang 050200，China
2. Dept. of Encephalopathy，Baoding First Hospital of Traditional Chinese Medicine，Hebei Baoding 071000，China
3. Preparation Room，Hebei Provincial Hospital of Traditional Chinese Medicine，Shijiazhuang 050011，China
4. Hebei Technology Innovation Center of TCM Formula Preparations，Shijiazhuang 050091，China
- Publication Type:Journal Article
- Keywords:
Maxing kechuan granules;
water extraction process;
Box-Behnken response surface method;
analytic hierarchy
- From:
China Pharmacy
2023;34(17):2095-2100
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To optimize the water extraction process of Maxing kechuan granules. METHODS With the contents of ephedrine hydrochloride， bergenin， prim-O-glucosylcimifugin， 5-O-methylvisamin， naringin and hesperidin and the rate of extraction as the evaluation indexes， the weight was determined by the analytic hierarchy process（APH）-entropy weight method， and the comprehensive score was calculated as the response value. Based on the single-factor test， the Box-Behnken response surface method was used to investigate the factors， and the best water extraction process of Maxing kechuan granules was optimized； process validation was also carried out. RESULTS The best water extraction process of Maxing kechuan granules optimized was as follows： soaking for 40 minutes， adding 8 times water， and extracting for 180 minutes. After three validation tests， the comprehensive score was 94.82 （RSD＝0.96%， n＝3）， which had a small difference from the predicted value of 94.64. CONCLUSIONS The water extraction process of Maxing kechuan granules is stable and reliable， which can provide a reference for the development of the preparation.
