Transmission of porcine endogenous retrovirus in xenotransplantation
10.3969/j.issn.1674-7445.2023293
- VernacularTitle:异种移植中猪内源性逆转录病毒的传播
- Author:
Yifan YU
1
;
Jiahua SONG
2
;
Xiangqin SONG
1
;
Tao LI
1
;
Jian JIANG
1
;
Yunhao BAI
1
;
Yi WANG
1
Author Information
1. Transplantation Institute, the Second Affiliated Hospital of Hainan Medical University, Hainan 570216, China.
2. .
- Publication Type:ReviewArticle
- Keywords:
Xenotransplantation;
Porcine endogenous retrovirus;
Organ shortage;
Transgene;
Transmission characteristics;
Zoonosis;
Immunodeficiency;
Infection
- From:
Organ Transplantation
2023;14(5):754-759
- CountryChina
- Language:Chinese
-
Abstract:
Organ transplantation is the most effective treatment for various types of end-stage diseases. To resolve the problem of donor shortage in organ transplantation, the possibility of xenotransplantation has been gradually explored by surgeons. Pig is one of the common donor sources for xenotransplantation. As a bridge between two species, the viruses carried by pig organs may be transmitted between species and cause the risk of zoonosis. Porcine endogenous retrovirus (PERV) is integrated into the genome, which is a category of retrovirus featuring cross-species transmission. In this article, the influencing factors of transmission characteristics of PERV, the transmission risk of PERV and its recombinant virus, and the detection and transmission risk assessment of PERV in xenotransplantation test were reviewed, aiming to provide reference for alleviating severe shortage of donor organs and driving the advancement of xenotransplantation technologies.
