Advances in application of regulatory T cells in transplant immune tolerance: from basic to clinical research
10.3969/j.issn.1674-7445.2023049
- VernacularTitle:从基础研究到临床实践：调节性T细胞在移植免疫耐受中的应用研究进展
- Author:
Lu HU
1
;
Yeqi NIAN
2
Author Information
1. The First Central Clinical College of Tianjin Medical University, Tianjin 300041, China.
2. .
- Publication Type:ReviewArticle
- Keywords:
Immune tolerance;
Regulatory T cell (Treg);
Organ transplantation;
Cell therapy;
Interleukin-2;
Chimeric antigen receptor (CAR);
Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4);
Graft-versus-host disease
- From:
Organ Transplantation
2023;14(5):745-753
- CountryChina
- Language:Chinese
-
Abstract:
Regulatory T cells (Treg) are important inhibitory immune cells to establish immune tolerance, which play a pivotal role in regulating excessive immune response and autoimmune diseases of the host. Previous studies related to transplant immune tolerance have confirmed that increasing the number of Treg in vivo or enhancing the function of Treg serve as a therapeutic strategy to induce transplant immune tolerance. At present, Treg-based induction methods for transplant immune tolerance include adoptive infusion of Treg, in vivo amplification of Treg and utilization of antigen-specific Treg. In this article, the characteristics and mechanism of Treg, the latest research progress on basic experiments and clinical practice of Treg related to transplant immune tolerance at home and abroad were reviewed, and future challenges and development of Treg therapy were prospected, aiming to unravel the significance and application prospect of Treg in transplant immune tolerance, explore the advantages and limitations of Treg therapeutic strategies, and provide reference and evidence for subsequent research in this field.
