The role of neutrophil extracellular trap in the diagnosis and treatment of complications after liver transplantation
10.3969/j.issn.1674-7445.2023093
- VernacularTitle:中性粒细胞胞外诱捕网在肝移植术后并发症诊疗中的作用
- Author:
Yanyao LIU
1
;
Xiaoyan QIN
2
;
Zhongjun WU
1
Author Information
1. Department of Hepatobiliary Surgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
2. null.
- Publication Type:ReviewArticle
- Keywords:
Liver transplantation;
Neutrophil extracellular trap;
Ischemia-reperfusion injury;
Acute rejection;
Acute liver failure;
Hepatocellular carcinoma;
Peptide arginine deiminase 4 (PAD 4);
Myeloperoxidase (MPO)
- From:
Organ Transplantation
2023;14(5):736-744
- CountryChina
- Language:Chinese
-
Abstract:
Prevention and treatment of complications after liver transplantation play a significant role in maintaining liver graft function and improving clinical prognosis of the recipients. Neutrophil extracellular trap (NET) are fibrous net-like structures composed of DNA as the skeleton and histones and granular proteins released by activated neutrophils. Studies have shown that the activation of neutrophils and the release of NET in donor liver after liver transplantation are involved in the incidence of multiple liver transplantation-related complications including ischemia-reperfusion injury, acute rejection, acute liver failure and recurrence of hepatocellular carcinoma, etc. In this article, the effect of NET on the complications after liver transplantation was mainly assessed, and research progress on NET as a potential target for the prevention and treatment of complications after liver transplantation was reviewed, aiming to provide reference for the prevention and treatment of complications after liver transplantation, enhance clinical efficacy of liver transplantation and improve clinical prognosis of the recipients.
