Effect of body mass index of recipients on early prognosis after lung transplantation
10.3969/j.issn.1674-7445.2023081
- VernacularTitle:受者体质量指数对肺移植术后早期预后的影响
- Author:
Dapeng WANG
1
;
Xiaoshan LI
2
;
Zhongping XU
1
;
Chenglong LIANG
1
;
Chunxiao HU
2
;
Hongyang XU
1
Author Information
1. Department of Intensive Care Unit, Wuxi People’s Hospital Affiliated to Nanjing Medical University, Wuxi 214023, China.
2. .
- Publication Type:OriginalArticle
- Keywords:
Body mass index;
Lung transplantation;
Recipient;
Early prognosis;
Survival rate;
Primary graft failure;
Obesity;
Malnutrition
- From:
Organ Transplantation
2023;14(5):669-675
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of body mass index (BMI) on early prognosis of the recipients after lung transplantation. Methods Clinical data of 307 lung transplant recipients were retrospectively analyzed. According to preoperative BMI, all recipients were divided into the low (BMI <18.5 kg/m2, n=114), normal (18.5 kg/m2≤BMI <24 kg/m2, n=145) and high (BMI≥24.0 kg/m2, n=48) BMI groups, respectively. Baseline data including age, sex, blood type, BMI, preoperative complications, preoperative pulmonary hypertension, and intraoperative use of extracorporeal membrane oxygenation (ECMO) of all recipients were compared among three groups. The survival rate of all recipients was estimated by Kaplan-Meier curve and the survival curve was delineated. The differences of survival rate were analyzed by log-rank test. The 30-, 90- and 180-d mortality risk of all recipients after lung transplantation in different BMI groups was compared by multivariate Cox regression analysis. Results There were significant differences in age and sex of recipients among three groups (both P<0.05). There was a significant difference regarding the 180-d survival rate after lung transplantation among different BMI groups (P<0.05). Multivariate Cox regression analysis showed that the 90-d mortality risk after lung transplantation in the high BMI group was 2.295 times higher than that in the normal BMI group [hazard ratio (HR) 2.295, 95% confidence interval (CI) 1.064-4.947, P=0.034]. In the high BMI group, the 180-d mortality risk after lung transplantation was 2.783 times higher compared with that in the normal BMI group (HR 2.783, 95%CI 1.333-5.810, P=0.006), and the 180-d mortality risk in the low BMI group was 2.181 times higher than that in the normal BMI group (HR 2.181, 95%CI 1.124-4.232, P=0.021). Conclusions Compared with the recipients with normal BMI, their counterparts with high and low preoperative BMI have higher mortality risk early after lung transplantation. Adjusting preoperative BMI to normal range contributes to improving early prognosis of lung transplant recipients.
