Effect of nuclear factor E2-related factor 2 on renal ischemia-reperfusion injury
10.3969/j.issn.1674-7445.2023124
- VernacularTitle:核因子E2相关因子2在肾缺血-再灌注损伤中的作用
- Author:
Xiaofeng LI
1
;
Guoxin ZHANG
2
;
Kaiyin YANG
2
;
Lingyun ZHANG
2
Author Information
1. First Clinical Medical College of Gansu University of Traditional Chinese Medicine, Lanzhou 730000, China.
2. .
- Publication Type:TransplantationForefront
- Keywords:
Kidney transplantation;
Nuclear factor E2-related factor 2;
Ischemia-reperfusion injury;
Acute kidney injury;
Oxidative stress;
Inflammation;
Cellular autophagy;
Cell apoptosis
- From:
Organ Transplantation
2023;14(5):656-661
- CountryChina
- Language:Chinese
-
Abstract:
Renal ischemia-reperfusion injury (RIRI) is the main cause of acute kidney injury (AKI), which commonly occurs in surgery, severe trauma, shock and drug-induced kidney injury. At present, effective treatment for RIRI is still lacking. Oxidative stress is the major pathological injury mechanism of RIRI. Nuclear factor E2-related factor 2 (Nrf2) is the key transcription factor of anti-oxidative stress response, which may activate various cytoprotective genes related to redox and detoxification. Recent studies have shown that Nrf2 may play a protective role in the protection and treatment of RIRI by regulating oxidative stress, inflammation, cell apoptosis and autophagy, etc. Consequently, the structure and biological function of Nrf2, related signaling pathways, its role in the incidence and development of RIRI and potential mechanism were reviewed in this article, aiming to provide novel ideas for the prevention and treatment of RIRI.
