In vivo transplantation of eye organoids and application of tissue engineering scaffolds
10.3969/j.issn.1674-7445.2023059
- VernacularTitle:眼类器官的体内移植及组织工程支架的应用
- Author:
Leyi HU
1
;
Zhenzhen LIU
1
;
Yizhi LIU
1
Author Information
1. Zhongshan Ophthalmic Centre, Sun Yat-sen University, State Key Laboratory of Ophthalmology, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou 510623, China.
- Publication Type:TransplantationForefront
- Keywords:
Eye organoid;
Blinding disease;
Stem cell;
In vitro culture;
In vivo transplantation;
Rejection;
Regenerative medicine;
Tissue engineering scaffold
- From:
Organ Transplantation
2023;14(5):649-655
- CountryChina
- Language:Chinese
-
Abstract:
Eye organoid refers to a structure that possesses resembling cell types and functions to intraocular tissues, which is induced by stem cells in vitro. Transplanting it into the body for eye repair and regeneration is one of the key research directions in regenerative medicine, which also provides a novel direction and strategy for the treatment of major blinding diseases. As a carrier of biological tissue or cell growth, tissue engineering scaffold could support in vivo transplantation of eye organoids and promote their maturation. Organic combination of eye organoids and tissue engineering is a critical approach to realize in vivo integration of eye organoids and reconstruct corresponding structures and functions. In this review, the latest research status of eye organoids and in vivo transplantation were summarized, and relevant studies of tissue engineering scaffold-assisted eye organoid transplantation were highlighted, aiming to provide ideas and reference for subsequent inter-disciplinary research of eye organoids and tissue engineering.
