Exploring the Pathogenesis of T2DM based on the Correlation between “Qi-fire Imbalance” and Ferroptosis
- VernacularTitle:从“气火失衡”与铁死亡的相关性探讨2型糖尿病的发病
- Author:
Xinhui SHEN
1
;
Jiren AN
1
;
Yufeng YANG
1
;
Qingfeng WANG
1
;
Hanwen ZHANG
1
;
Jiaxiang YU
1
;
Cheng ZHOU
1
;
Hui ZHANG
1
;
Mingdan GUAN
1
;
Yan SHI
1
Author Information
- Publication Type:Journal Article
- Keywords: type 2 diabetes mellitus; ferroptosis; yin fire; qi and fire imbalance; oxidative stress; lipid peroxidation
- From: Journal of Tradition Chinese Medicine 2023;64(17):1759-1762
- CountryChina
- Language:Chinese
- Abstract: Ferroptosis is a novel iron-dependent mode of programmed cell death characterized by iron deposition and accumulation of lipid peroxidation. More and more studies have found that ferroptosis is closely related to the pathogenesis of type 2 diabetes mellitus （T2DM）. The yin-fire theory is an important part of LI Gao's spleen-stomach theory， and it is believed that qi-fire imblance and yin-fire internal generation is the main pathogenesis of T2DM. Abnormal iron metabolism may be an important prerequisite for T2DM yin-fire internal generation， while oxidative stress is the specific manifestation of T2DM qi-fire imbalance. Reactive oxygen species （ROS） is the end product of qi-fire imbalance， and lipid peroxide is the pathological products of T2DM yin-fire internal generation. This study intends to explore the pathological mechanism of qi-fire imbalance and yin-fire internal generation from the perspectives of iron metabolism， oxidative stress and lipid peroxidation， enriching the modern connotation of yin-fire theory， and benefiting traditional Chinese medicine to target against ferroptosis， and prevent and treat T2DM precisely.
- Full text:7. Exploring the Pathogenesis of T2DM based on the Correlation between “Qi-fire Imbalance” and Ferroptosis.pdf
