Diagnostic study of actinic cheilitis by reflectance confocal microscopy
10.12016/j.issn.2096-1456.2023.11.007
- Author:
ZHANG Muyang
1
,
2
;
WANG Haiyan
1
,
2
;
JIANG Weiwen
1
,
2
Author Information
1. Department of Oral Mucosal Diseases, Shanghai Ninth People&rsquo
2. s Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology
- Publication Type:Journal Article
- Keywords:
actinic cheilitis / reflectance confocal microscopy / keratotic lesions / solar elastosis / inflammatory infiltration / pathological features / non-invasive / diagnostic techniques
- From:
Journal of Prevention and Treatment for Stomatological Diseases
2023;31(11):807-812
- CountryChina
- Language:Chinese
-
Abstract:
Objective :To explore the clinical application value of reflectance confocal microscopy(RCM) in the diagnosis of actinic cheilitis(AC).
Methods:After approval by the hospital ethics committee and informed consent given by the patients, from October 2020 to July 2022, 17 patients who were diagnosed with actinic cheilitis in the Ninth People's Hospital affiliated with Shanghai Jiao Tong University School of Medicine were retrospectively analyzed. The white keratotic lesions of the lips were scanned with reflectance confocal microscopy, and the image characteristics were summarized and analyzed, including epithelial hyperplasia/atrophy, hyperkeratosis, inflammatory cell infiltration, blood vessel dilatation, solar elastosis, atypical keratinocytes, widening of intercellular spaces, degeneration of basal cell layer, and pigmentation. We used the sample compliance rate to measure the correlation between RCM parameters and histopathological diagnostic criteria for AC and kappa concordance analysis to calculate the concordance between RCM and pathological diagnosis.
Results: Under RCM, the sample correct rates for epithelial hyperplasia/atrophy, hyperkeratosis, inflammatory cell infiltration, vasodilation, and solar elastosis were 76.5%, 100%, 100%, 64.7%, and 70.6%, the sample accuracy compared with pathological diagnosis was 82.4%, 47.1%, 94.1%, 88.2% and 76.5%, respectively. We also observed that 100%, 88.2%, 76.5%, and 88.2% of AC patients showed RCM features of atypical keratinocytes, widening of intercellular spaces, degeneration of the basal cell layer, and pigmentation, respectively. The kappa value of hyperkeratosis and inflammatory cell infiltration was 1. The kappa value of blood vessel dilatation was 0.645.
Conclusion :Reflectance confocal microscopy is noninvasive and versatile and has clinical application value in the diagnosis of actinic cheilitis.
- Full text:反射式共聚焦显微镜对光化性唇炎的诊断研究.pdf
