Electroencephalographic microstates in vestibular schwannoma patients with tinnitus.
10.12122/j.issn.1673-4254.2023.05.15
- Author:
Chi ZHANG
1
;
Xiaoguang WANG
2
;
Zhiwei DING
3
;
Hanwen ZHOU
3
;
Peng LIU
3
;
Xinmiao XUE
3
;
Wei CAO
1
;
Yuhua ZHU
1
;
Jiyue CHEN
1
;
Weidong SHEN
1
;
Shiming YANG
1
;
Fangyuan WANG
1
Author Information
1. The First Medical Center, Chinese PLA General Hospital, Beijing 100853, China.
2. Medical School of Chinese PLA, Beijing 100853, China.
3. The Sixth Medical Center, Chinese PLA General Hospital, Beijing 100048, China.
- Publication Type:Journal Article
- Keywords:
electroencephalogram;
microstates;
tinnitus;
vestibular schwannoma
- MeSH:
Humans;
Neuroma, Acoustic/complications*;
Electroencephalography;
Patients;
Probability
- From:
Journal of Southern Medical University
2023;43(5):793-799
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the biomarkers of tinnitus in vestibular schwannoma patients using electroencephalographic (EEG) microstate technology.
METHODS:The EEG and clinical data of 41 patients with vestibular schwannoma were collected. All the patients were evaluated by SAS, SDS, THI and VAS scales. The EEG acquisition time was 10-15 min, and the EEG data were preprocessed and analyzed using MATLAB and EEGLAB software package.
RESULTS:Of the 41 patients with vestibular schwannoma, 29 patients had tinnitus and 12 did not have tinnitus, and their clinical parameters were comparable. The average global explanation variances of the non-tinnitus and tinnitus groups were 78.8% and 80.1%, respectively. The results of EEG microstate analysis showed that compared with those without tinnitus, the patients with tinnitus had an increased frequency (P=0.033) and contribution (P=0.028) of microstate C. Correlation analysis showed that THI scale scores of the patients were negatively correlated with the duration of microstate A (R=-0.435, P=0.018) and positively with the frequencies of microstate B (R=0.456, P=0.013) and microstate C (R=0.412, P=0.026). Syntax analysis showed that the probability of transition from microstate C to microstate B increased significantly in vestibular schwannoma patients with tinnitus (P=0.031).
CONCLUSION:EEG microstate features differ significantly between vestibular schwannoma patients with and without tinnitus. This abnormality in patients with tinnitus may reflect the potential abnormality in the allocation of neural resources and the transition of brain functional activity.
