Associations between Oxidized LDL to LDL Ratio, HDL and Vascular Calcification in the Feet of Hemodialysis Patients.
10.3346/jkms.2009.24.S1.S115
- Author:
Won Suk AN
1
;
Seong Eun KIM
;
Ki Hyun KIM
;
Hae Rahn BAE
;
Seo Hee RHA
Author Information
1. Department of Internal Medicine, Dong-A University, Busan, Korea. anws@dau.ac.kr
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Vascular Calcification;
Oxidized Low Density Lipoprotein;
High Density Lipoproteins;
Hemodialysis
- MeSH:
Aged;
C-Reactive Protein/metabolism;
Cardiovascular Diseases/blood/complications/diagnosis;
Female;
Foot;
Humans;
Kidney Failure, Chronic/blood/complications/diagnosis;
Lipoproteins, HDL/*metabolism;
Lipoproteins, LDL/*metabolism;
Male;
Middle Aged;
Plasminogen Activator Inhibitor 1/metabolism;
*Renal Dialysis;
Risk Factors
- From:Journal of Korean Medical Science
2009;24(Suppl 1):S115-S120
- CountryRepublic of Korea
- Language:English
-
Abstract:
Cardiovascular mortality is associated with vascular calcification (VC) in hemodialysis (HD) patients. The present study was designed to find factors related with medial artery calcification on the plain radiography of feet by comparing C-reactive protein (CRP), plasminogen activator inhibitor type 1 (PAI-1) and lipid profile including oxidized low density lipoprotein (ox-LDL) and to elucidate associations among these factors in HD patients. Forty-eight HD patients were recruited for this study. VC in the feet was detected in 18 patients (37.5%) among total patients and 12 patients (85.7%) among diabetic patients. Diabetes, cardiovascular disease (CVD), pulse pressure, ox-LDL/LDL were higher and high density lipoprotein (HDL) was lower in patients with VC than in patients without VC. Negative associations were found between HDL and CRP, PAI-1. PAI-1 had positive association with ox-LDL/LDL. History of CVD was the only determinant of vascular calcification on the plain radiography of feet. Ox-LDL/LDL, HDL, CRP, and PAI-1 were closely related with one another in HD patients. History of CVD is the most important factor associated with the presence of VC and low HDL and relatively high oxidized LDL/LDL ratio may affect VC formation on the plain radiography in the feet of HD patients.
