Post-treatment Effects of Erythropoietin and Nordihydroguaiaretic Acid on Recovery from Cisplatin-induced Acute Renal Failure in the Rat.
10.3346/jkms.2009.24.S1.S170
- Author:
Dong Won LEE
1
;
Ihm Soo KWAK
;
Soo Bong LEE
;
Sang Heon SONG
;
Eun Young SEONG
;
Byeong Yun YANG
;
Min Young LEE
;
Mee Young SOL
Author Information
1. Department of Internal Medicine, Pusan National University School of Medicine, Busan, Korea. iskwak@pusan.ac.kr
- Publication Type:Original Article
- Keywords:
Kidney Failure, Acute;
Cisplatin;
Erythropoietin;
Nordihydroguaiaretic Acid
- MeSH:
Animals;
Arachidonate 5-Lipoxygenase/administration & dosage;
Blood Urea Nitrogen;
Cisplatin/*toxicity;
Creatinine/urine;
Epithelial Cells/drug effects;
Erythropoietin/administration & dosage/*therapeutic use;
Kidney/metabolism;
Kidney Failure, Acute/*chemically induced/*drug therapy;
Kidney Tubules/drug effects;
Male;
Nordihydroguaiaretic Acid/*therapeutic use;
Rats;
Rats, Sprague-Dawley;
Regeneration
- From:Journal of Korean Medical Science
2009;24(Suppl 1):S170-S175
- CountryRepublic of Korea
- Language:English
-
Abstract:
5-Lipoxygenase inhibitor and human recombinant erythropoietin might accelerate renal recovery in cisplatin-induced acute renal failure rats. Male Sprague-Dawley rats were randomized into four groups: 1) normal controls; 2) Cisplatin group-cisplatin induced acute renal failure (ARF) plus vehicle treatment; 3) Cisplatin+nordihydroguaiaretic acid (NDGA) group-cisplatin induced ARF plus 5-lipoxygenase inhibitor treatment; 4) Cisplatin+erythropoietin (EPO) group-cisplatin induced ARF plus erythropoietin treatment. On day 10 (after 7 daily injections of NDGA or EPO), urea nitrogen and serum Cr concentrations were significantly lower in the Cisplatin+NDGA and Cisplatin+EPO groups than in the Cisplatin group, and 24 hr urine Cr clearances were significantly higher in the Cisplatin+EPO group than in the Cisplatin group. Semiquantitative assessments of histological lesions did not produce any significant differences between the three treatment groups. Numbers of PCNA(+) cells were significantly higher in Cisplatin, Cisplatin+NDGA, and Cisplatin+EPO groups than in normal controls. Those PCNA(+) cells were significantly increased in Cisplatin+NDGA group. These results suggest that EPO and also NDGA accelerate renal function recovery by stimulating tubular epithelial cell regeneration.
