Advances in the study of the roles of mitochondrial dysfunction and neuroinflammation in the pathogenesis of schizophrenia
10.11886/scjsws20220721001
- VernacularTitle:线粒体功能障碍与神经炎症在精神分裂症发病机制中的研究进展
- Author:
Keke HAO
1
;
Huiling WANG
1
;
Gaohua WANG
1
Author Information
1. Renmin Hospital of Wuhan University， Wuhan 430060， China
- Publication Type:Review
- Keywords:
Schizophrenia;
Immuno-inflammation;
Mitochondria;
Microglia
- From:
Sichuan Mental Health
2023;36(1):74-79
- CountryChina
- Language:Chinese
-
Abstract:
This paper aims to present a review of the research progress on the roles of mitochondrial dysfunction and microglia-mediated inflammation in the pathophysiology of schizophrenia. Schizophrenia is a serious psychiatric disorder in which the immuno-inflammatory pathway is considered to be one of the main pathogenic mechanisms of disease， and manifested by microglia activation and elevated levels of inflammatory cytokines in the brain. However， the biological mechanism underlying immune disorder in schizophrenia has not been fully elucidated. In recent years， accumulating evidence has indicated that mitochondrial dysfunction may play a key role in the pathogenesis of schizophrenia. Therefore， this article reviews the research progress on the roles of mitochondrial days function and microglia-mediated inflammation in the pathophysiology of schizophrenia， so as to inform the study of the pathogenesis of schizophrenia.
