Trajectories of glucose and lipid metabolism of schizophrenic patients in long-term hospitalization： a real-world study
10.11886/scjsws20230218003
- VernacularTitle:长期住院的精神分裂症患者糖脂代谢变化轨迹：一项真实世界研究
- Author:
Xiaoying YE
1
;
Weiqun TAO
1
;
Qingqing ZHANG
2
;
Yingjia YANG
2
;
Xinhui XIE
3
;
Binrang YANG
4
Author Information
1. Shantou University Medical College， Shantou 515041， China
2. Shenzhen Mental Health Center/Shenzhen Kangning Hospital， Shenzhen 518020， China
3. Renmin Hospital of Wuhan University， Wuhan 430060， China
4. Shenzhen Children's Hospital， Shenzhen 518034， China
- Publication Type:Journal Article
- Keywords:
Schizophrenia;
Patients in long-term hospitalization;
Glucose metabolism;
Lipid metabolism;
Real-world study
- From:
Sichuan Mental Health
2023;36(2):111-117
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo picture the trajectory of changes in glucose and lipid metabolism among schizophrenic patients in long-term hospitalization. MethodsA total of 109 inpatients of Shenzhen Kangning Hospital from 2014 to 2022， who were diagnosed with schizophrenia based on the International Classification of Diseases， tenth edition （ICD-10） criteria， were recruited as subjects. Real-world follow-up data on longitudinal glucose metabolism （fasting blood glucose， glycosylated hemoglobin， C-peptide） and lipid metabolism （triglycerides， low density lipoprotein， high density lipoprotein， total cholesterol） were observed. The frequency of visit was once a year， with a total of 9 visits over 8 years. ResultsIn terms of glucose metabolism parameters， fasting blood glucose level decreased to 4.87 mmol/L at the 7th visit， lower than the baseline level （P<0.01）. Glycated hemoglobin level was 6.08% at the 9th visit， higher than the baseline level （P<0.05）. C-peptide level was 3.14 ng/mL at the 7th visit， higher than the baseline level （P<0.01）. As for the trajectory of lipid metabolism parameters， high-density lipoprotein level were significantly lower than baseline level at the second visit （P<0.01） and stayed basically stable thereafter. Total cholesterol levels at the last three visits were 4.06， 4.07 and 3.95 mmol/L， respectively， all lower than the baseline level （P<0.01）. ConclusionThe changes of glycolipid metabolism parameters in long-term inpatients with schizophrenia were generally smooth during the 8-year follow-up period.
