Clinical Observation of 32 Cases of Malignant Lymphoma Treated with Brentuximab Vedotin Combined with Chemotherapy
10.3971/j.issn.1000-8578.2023.22.1235
- VernacularTitle:维布妥昔单抗联合化疗治疗32例恶性淋巴瘤的临床观察
- Author:
Xiaofei CHAI
1
;
Honghan QIAO
;
Lei ZHANG
;
Xin LI
;
Ling LI
;
Xinhua WANG
;
Xiaorui FU
;
Xudong ZHANG
;
Zhenchang SUN
;
Feifei NAN
;
Mingzhi ZHANG
Author Information
1. Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
- Publication Type:Research Article
- Keywords:
Brentuximab vedotin;
Antibody-drug conjugate;
Lymphoma;
Prognosis
- From:
Cancer Research on Prevention and Treatment
2023;50(3):288-292
- CountryChina
- Language:Chinese
-
Abstract:
Objective To retrospectively evaluate the clinical efficacy and safety of brentuximab vedotin(BV) combined with chemotherapy in the treatment of malignant lymphoma. Methods We collected the data of 32 lymphoma patients with CD30-positive status, including 14 cases of Hodgkin's lymphomas, 2 cases of diffuse large B-cell lymphomas, and 16 cases of mature T/NK cell lymphomas. Chemotherapy combined with BV was administered to all patients for a minimum of two cycles. The efficacy of the treatment was evaluated according to Lugano criteria every two cycles. Results Complete response rate and overall response rate after four cycles of treatment were 22% and 50%, respectively. Sixteen cases (50.0%) had grades 1 and 2 toxicity, and 16 cases (50.0%) had grade 3 toxicity or higher. The most common adverse events were neutropenia (50.0%), pneumonia (46.9%), and anemia (43.8%). The most common grade 3 or higher adverse events were pneumonia (18.8%) and febrile neutropenia (12.5%). Four patients discontinued brentuximab vedotin because of severe adverse events. Conclusion BV is effective in treating relapsed and refractory CD30- positive Hodgkin's lymphoma and peripheral T-cell lymphoma, and its overall safety is acceptable.
