Research Progress of Targeting uPA-uPAR System in Tumor Therapy
10.3971/j.issn.1000-8578.2023.22.0737
- VernacularTitle:靶向uPA-uPAR系统在肿瘤治疗中的研究进展
- Author:
Weiwen CAI
1
;
Long QIN
;
Junchang ZHANG
;
Fei WEN
;
Wentao ZHANG
;
Zuoyi JIAO
Author Information
1. Department of General Surgery, Lanzhou University Second Hospital, Lanzhou 730000, China
- Publication Type:Research Article
- Keywords:
uPA;
uPAR;
PAI-1;
Tumor;
Targeting therapy
- From:
Cancer Research on Prevention and Treatment
2023;50(2):202-208
- CountryChina
- Language:Chinese
-
Abstract:
The uPA-uPAR system is highly expressed in various tumor tissues. This system can promote the degradation of extracellular matrix proteins, as well as combine with vitronectin and integrin to transmit intracellular signal transduction. Subsequently, it mediates the occurrence and development of tumors. In recent years, a series of therapeutic programs that target this system has achieved notable results in tumor treatment, and some of them have been under the clinical trial stage, thus providing new ideas for tumor targeted therapy. Therefore, this paper intends to provide a review of research progress on the gene therapy, drug therapy, and immunotherapy targeting uPA-uPAR system.
