Research Progress on Crotonylation in Malignant Tumor
10.3971/j.issn.1000-8578.2023.22.0770
- VernacularTitle:巴豆酰化修饰在恶性肿瘤中的研究进展
- Author:
Fangyuan LIU
1
;
Liya SU
Author Information
1. Research Center for Clinical Medicine, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010010, China
- Publication Type:Research Article
- Keywords:
Crotonylation;
Malignant tumors;
Protein;
Posttranslational modification
- From:
Cancer Research on Prevention and Treatment
2023;50(2):195-201
- CountryChina
- Language:Chinese
-
Abstract:
As a newly discovered posttranslational modification (PTM), crotonylation has been identified in histone and nonhistone proteins and has important roles in the regulation of various diseases and biological processes. With the development of high-resolution mass spectrometry approaches, an increasing number of endogenous crotonylation has been detected and identified. The discovery of crotonylation regulatory enzymes paved the way for the study of crotonylation mechanism. In this review, we summarize the biological functions and regulatory mechanism of crotonylation in eukaryotes and introduce the recent progress on crotonylation in malignant tumor.
