Effect of PD1-TCF1+CD8+ Stem-like Memory T Cells on Immunotherapy Prognosis and Tertiary Lymphoid Structures in Tumors
10.3971/j.issn.1000-8578.2023.22.0815
- VernacularTitle:PD1-TCF1+CD8+干细胞样记忆T细胞对肿瘤患者免疫预后及三级淋巴结构的影响
- Author:
Xue CUI
1
;
Yiming WENG
;
Peiwei WANG
;
Min PENG
Author Information
1. Department of Oncology, Renmin Hospital of Wuhan University, Wuhan 430060, China
- Publication Type:Research Article
- Keywords:
Tumor microenvironment;
Prognosis;
Tertiary lymphoid structures;
Stem cell-like memory T cell
- From:
Cancer Research on Prevention and Treatment
2023;50(2):146-150
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the impact of PD1-TCF1+CD8+ stem-like memory T cells on immunotherapy prognosis and tertiary lymphoid structure in tumors. Methods Pathological tissue sections were collected from 33 patients treated with immunotherapy, 18 cases of NSCLC and 15 cases of ESCC. The expression of PD1-TCF1+CD8+T cells was detected through quantitative analysis by multiplex immunofluorescence. Survival curves were described by the Kaplan-Meier method. Pearson's correlation test was used for correlation analysis. Results The high levels of PD1-TCF1+CD8+T cells had a better PFS in NSCLC and ESCC cohorts. In the NSCLC cohort, high levels of PD1-TCF1+CD8+ T cells were significantly and positively correlated with the number (P=0.0151) and size (P=0.0007) of TLSs. Conclusion In patients with NSCLC and ESCCs, high PD1-TCF1+CD8+ stem-like memory T cell expression indicates improved prognosis and immune response and is associated with the formation of TLSs in the tumor microenvironment of NSCLC.
