Expression of PD-L1 in Primary Colorectal Cancer and Its Predictive Value for Recurrence After Microwave Ablation of Liver Metastases
10.3971/j.issn.1000-8578.2023.22.0538
- VernacularTitle:PD-L1在结直肠癌原发灶中的表达及对肝转移微波消融术后复发的预测价值
- Author:
Jianwei REN
1
;
Zubang ZHOU
;
Wenjuan MA
;
Daxiong YANG
;
Yiqun REN
;
Zhi ZHANG
;
Yanqiang NIU
;
Lei CAO
Author Information
1. The First Clinical Medical College of Gansu University of Chinese Medicine, Lanzhou 730000, China
- Publication Type:Research Article
- Keywords:
PD-L1;
Colorectal cancer;
Liver metastases;
Microwave ablation;
Recurrence
- From:
Cancer Research on Prevention and Treatment
2023;50(1):38-42
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of programmed death ligand 1(PD-L1) in primary tumor cells(TCs) and tumor-infiltrating immune cells(TICs) in patients with liver metastases from colorectal cancer(CRC) and determine its predictive value for recurrence after microwave ablation(MWA) of liver metastases. Methods The paraffin-embedded specimens of 28 patients with CRC liver metastasis were collected retrospectively. The expression of PD-L1 in the primary lesions was detected by immunohistochemistry, and the relationship between PD-L1 and clinical features was analyzed. Recurrence-free survival(RFS) was analyzed by Kaplan-Meier method and Log rank test. Cox proportional hazards regression model was used to analyze the factors influencing recurrence. Results The positive rates of PD-L1 in TCs and TICs in primary CRC were 14.3%(4/28) and 46.4%(13/28), respectively. PD-L1 expression in primary TICs of CRC patients with liver metastases was significantly correlated with the largest hepatic tumor diameter (P < 0.05). PD-L1 expression in primary TICs of CRC patients with liver metastasis was correlated with poor RFS after MWA (P < 0.05). PD-L1 expression in primary TICs and the largest hepatic tumor diameter > 3 cm in CRC patients with liver metastases were the risk factors for recurrence after MWA (P < 0.05). Conclusion PD-L1 expression in primary TICs of CRC patients with liver metastasis may increase the risk of recurrence after MWA for liver metastasis.
