Advances of Immunotherapy for Non-small Cell Lung Cancer with Driver Gene Mutations
10.3971/j.issn.1000-8578.2023.22.1033
- VernacularTitle:驱动基因突变非小细胞肺癌免疫治疗的研究进展
- Author:
Chunxia SU
1
;
Xin YU
Author Information
1. Department of Oncology, Shanghai Pulmonary Hospital & Thoracic Cancer Institute, Tongji University School of Medicine, Shanghai 200433, China
- Publication Type:Research Article
- Keywords:
Non-small cell lung cancer;
Driver gene mutation;
Immunotherapy
- From:
Cancer Research on Prevention and Treatment
2023;50(1):1-5
- CountryChina
- Language:Chinese
-
Abstract:
With the discovery of lung cancer targets and drug development, targeted therapy has improved the clinical prognosis of non-small cell lung cancer (NSCLC) with driver gene mutations. Immune checkpoint inhibitors (ICIs) have shown good efficacy in driver gene-negative NSCLC. Although some patients with driver gene mutations benefited significantly from the corresponding targeted therapy, they did not respond well to immunotherapy. In most clinical trials and daily practice, patients with NSCLC and driver gene mutations such as EGFR and ALK are excluded or only account for a minority of patients. Applying immunotherapy to patients with driver gene mutations, selecting the best treatment regimens among targeted therapy, chemotherapy, and immunotherapy, and formulating the optimal treatment strategy are crucial to improve the prognosis of patients with advanced NSCLC and driver gene mutations. This paper reviews the characteristics of tumor immune microenvironment with different driver gene mutations and the application of immunotherapy for patients with NSCLC and different driver gene mutations.
