Biological Mechanism of Pyroptosis and Its Research Progress in Breast Cancer
10.3971/j.issn.1000-8578.2022.22.0485
- VernacularTitle:细胞焦亡的生物学机制及其在乳腺癌中的研究进展
- Author:
He DOU
1
;
Shuang MA
;
Yue ZHU
;
Yuqi LIU
;
Min XIAO
Author Information
1. Department of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin 150086, China
- Publication Type:Research Article
- Keywords:
Pyroptosis;
Caspase;
Programmed cell death;
Breast cancer
- From:
Cancer Research on Prevention and Treatment
2022;49(11):1175-1179
- CountryChina
- Language:Chinese
-
Abstract:
Pyroptosis is a newly discovered way of proinflammatory programmed cell death. Pyroptosis is mediated by caspase-1 (Caspase-1). Through the cleavage and activation of GSDM family proteins, small pores are formed on the cell membrane, thus rapid lysis of the cell membrane process, and then leads to intracellular inflammatory content release thereby causing inflammatory response. The three pyroptosis pathways are the classical pathway of Caspase-1, the non-classical pathway of Caspase-4, 5, and 11, and the special pathway of Caspase-3 or Hela cells. Pyroptosis plays an important role in the occurrence, invasion, and metastasis of breast cancer, and is closely related to the prevention and treatment of breast cancer. This article reviews the biological mechanism of pyroptosis and its research progress in breast cancer, to provide a new idea for clinicians in the treatment of breast cancer.
