Progress on Correlation Between Type 2 Diabetes Mellitus and Malignant Tumors
10.3971/j.issn.1000-8578.2022.21.1324
- VernacularTitle:糖尿病与肿瘤关系的研究进展
- Author:
Han ZHOU
1
;
Deqiao SHENG
Author Information
1. Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, Medical College, China Three Gorges University, Yichang 443002, China
- Publication Type:Research Article
- Keywords:
Type 2 diabetes mellitus;
Tumor;
Hyperglycemia;
Hyperinsulinemia;
Chronic inflammation;
Gut microbiome
- From:
Cancer Research on Prevention and Treatment
2022;49(11):1107-1111
- CountryChina
- Language:Chinese
-
Abstract:
Type 2 diabetes mellitus and malignant tumors are two kinds of chronic diseases with tremendous impact on human health. Numerous epidemiological and clinical studies have shown that type 2 diabetes mellitus increases the risk of liver, pancreatic, endometrial, gallbladder, colorectal and breast cancers. Hyperglycemia can promote cancer cell proliferation, migration, invasion and immune escape through a variety of direct and indirect mechanisms. Insulin resistance and hyperinsulinemia can activate multiple signal transduction pathways through insulin/IGF-I signaling axis and promote tumorigenesis. Sustained chronic inflammatory responses can promote the development of cancer through DNA damage and pro-inflammatory factors. Gut microbiome dysbiosis is closely related to the occurrence of several gastrointestinal tumors. This paper reviews the progress on the correlation between type 2 diabetes mellitus and the progression of malignant tumors and the possible mechanisms.
