Interaction and Targeting Strategies of Colorectal Cancer Stem Cells and Tumor Microenvironment
10.3971/j.issn.1000-8578.2022.22.0102
- VernacularTitle:结直肠癌干细胞和肿瘤微环境的相互影响及靶向策略
- Author:
Nie XU
1
;
Yongjun ZENG
Author Information
1. The Second Department of Oncology, Integrated TCM & Western Medicine Hospital Affiliated to Chengdu University of TCM, Chengdu 610000, China
- Publication Type:Research Article
- Keywords:
Colon cancer stem cell;
Tumor microenvironment;
Targeted therapy
- From:
Cancer Research on Prevention and Treatment
2022;49(10):1077-1081
- CountryChina
- Language:Chinese
-
Abstract:
Colorectal cancer stem cells are undifferentiated tumorigenic cells with malignant phenotypic characteristics in colorectal cancer and considered as the main cause of tumor recurrence, drug resistance, and metastasis through self-renewal and differentiated cloning. Colorectal cancer stem cells and various components in the tumor microenvironment are interdependent and influence one another. The relationship between tumor stem cells and other components in the tumor microenvironment may play an important role in the treatment of colorectal cancer. This review summarizes this relationship.
