Research Progress on Influence of DNA Methylation on Signal Pathways Related to Invasion and Metastasis of Nasopharyngeal Carcinoma
10.3971/j.issn.1000-8578.2022.22.0052
- VernacularTitle:DNA甲基化影响鼻咽癌侵袭转移相关信号通路的研究进展
- Author:
Zihe WANG
1
;
Zengliang LI
;
Xuzhe FANG
;
Jin ZHU
Author Information
1. Department of Otorhinolaryngology, The Fourth Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou 310006, China
- Publication Type:Research Article
- Keywords:
DNA methylation;
Nasopharyngeal carcinoma;
Signaling pathway;
Invasion and metastasis
- From:
Cancer Research on Prevention and Treatment
2022;49(9):956-960
- CountryChina
- Language:Chinese
-
Abstract:
Nasopharyngeal carcinoma (NPC) is one of the most common malignant tumors of the head and neck region. NPC has the characteristics of insidious onset, strong invasiveness and early lymph node metastasis. A variety of signaling pathways play a role in the invasion and metastasis of nasopharyngeal carcinoma, but the specific mechanism has not yet been fully elucidated. Recent studies have found that DNA methylation of nasopharyngeal carcinoma-related genes can affect the invasion and metastasis of nasopharyngeal carcinoma through a variety of signaling pathways including Wnt/β-catenin, PI3K/AKT and MAPK signaling pathways. This article reviews the specific mechanism of DNA methylation affecting the invasion and metastasis of nasopharyngeal carcinoma through the above-mentioned signaling pathways.
