Diagnosis Value of Tumor-associated Auto-antibodies Combined with Low-dose Spiral Computed Tomography in Early Lung Cancer Screening
10.3971/j.issn.1000-8578.2022.22.0060
- VernacularTitle:血清自身抗体联合低剂量螺旋CT在肺癌早期筛查中的价值
- Author:
Na ZHAN
1
;
Wei XU
;
Zhi ZENG
;
Liling DONG
Author Information
1. Department of Pathology, Renmin Hospital of Wuhan University, Wuhan 430060, China
- Publication Type:Research Article
- Keywords:
Serum autoantibody detection;
Low-dose spiral CT;
Early stage lung cancer;
High-risk population
- From:
Cancer Research on Prevention and Treatment
2022;49(9):908-912
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the application value of serum auto-antibody detection combined with low-dose spiral computed tomography (LDCT) in early lung cancer screening. Methods From 12568 medical examination crowd (7453 males and 5115 females), 1324 people with high-risk cases of lung cancer in our medical examination center were divided randomly into three groups (LDCT, serum auto-antibody, and serum auto-antibody combined with LDCT groups). All people in this research were screened by chest X-ray. Follow-up was conducted for one year, and the positive screening and diagnosis rates of early lung cancer screening were compared between these groups of high-risk people with lung cancer. Results The positive screening and diagnostic rates of high-risk lung cancer in the serum auto-antibody combined with LDCT group was significantly higher those that in other two groups (P < 0.001). The specificity and sensitivity of serum auto-antibody combined with LDCT group were 89.1% and 88.4%, respectively; the area under the ROC curve was 0.863. Conclusion Serum auto-antibody detection combined with low-dose spiral CT can significantly improve the positive screening rate of lung cancer in high-risk populations, providing a strong theoretical support for lung cancer screening pathway.
