Establishment of Endoscopic Surgical Innovative System of Recurrent Nasopharyngeal Carcinoma
10.3971/j.issn.1000-8578.2022.22.0468
- VernacularTitle:内镜下复发性鼻咽癌外科治疗创新体系建设
- Author:
Huankang ZHANG
1
;
Kun DU
;
Quan LIU
;
Kai XUE
;
Ye GU
;
Weidong ZHAO
;
Wanpeng LI
;
Xiaole SONG
;
Keqing ZHAO
;
Han LI
;
Li HU
;
Qiang LIU
;
Huapeng YU
;
Yurong GU
;
Xicai SUN
;
Hongmeng YU
Author Information
1. Department of Otolaryngology, Eye & ENT Hospital, Fudan University, Shanghai 200031, China
- Publication Type:Research Article
- Keywords:
Recurrent nasopharyngeal carcinoma;
Endoscopic surgery;
Internal carotid artery;
Temporalis muscle flap;
Skull base repair
- From:
Cancer Research on Prevention and Treatment
2022;49(9):863-869
- CountryChina
- Language:Chinese
-
Abstract:
Nasopharyngeal carcinoma (NPC) is a common malignant tumor in China. Radiotherapy is the first-line treatment. After appropriate radiotherapy, about 5%-15% patients experience recurrence. In view of the poor efficacy and high incidence of severe late toxicities associated with re-irradiation, salvage surgery by the transnasal endoscopic approach is recommended for recurrent NPC (rNPC). Compared with re-irradiation, endoscopic surgery can better prolong survival, improve the quality of life, and reduce complications and medical expenses of patients with rNPC. However, the complexity of the nasopharyngeal skull base enhances the difficulty and risk of surgery. Expanding the boundary of surgical resection remains a clinical challenge for otolaryngologists. In this regard, to help more advanced patients with rNPC, the surgical innovative system of NPC needs to be established by multi-disciplinary cooperation, involving skull base anatomy-based investigation, appropriate administration of the internal carotid artery (ICA), repair of skull base defect, and establishment of various types of endoscopic endonasal nasopharyngectomy.
