Research Progress on Mechanism of Mitochondrial DNA in Occurrence and Development of Digestive System Malignant Tumors
10.3971/j.issn.1000-8578.2022.22.0542
- VernacularTitle:线粒体DNA在消化系恶性肿瘤发生发展中的作用机制研究进展
- Author:
Lingxiao WANG
1
;
Yingjia WANG
;
Jian YANG
;
Yaoping LI
Author Information
1. The Fifth Clinical Medical College of Shanxi Medical University, Taiyuan 030012, China
- Publication Type:Research Article
- Keywords:
mt-DNA;
Digestive system malignancies;
Cancer;
Early detection;
Clinical translation application
- From:
Cancer Research on Prevention and Treatment
2022;49(8):838-842
- CountryChina
- Language:Chinese
-
Abstract:
Mitochondrial DNA (mt-DNA) is an important carrier of extranuclear genetic information. Recent research results show that mt-DNA is closely related to the occurrence and metastasis of various malignant tumors, and can be used for early diagnosis and targeted therapy of cancer. Therefore, further research on the mechanism of mt-DNA in digestive system malignant tumors has important clinical significance for screening and identifying tumor molecular markers for anti-tumor drug targets, cancer diagnosis and prognosis analysis. This article reviews the research progress on the potential relationship, clinical application and therapeutic targets of mt-DNA and digestive system malignancies.
